- Do certain individuals have better or improved control of infection and disease due to variation?
- Are there certain pathogen variants that predispose to disease and do these interact with human variation?
- Can we gain insight towards developing and evaluating novel therapeutics and vaccines?
- Can we leverage high-throughput genomics to inform public responses?
Malaria Genetics and GenomicsThe main focus of our lab is malaria genomics within a large network of collaborators. Plasmodium falciparum and Plasmodium vivax are eukaryotic red cell parasites that still causes significant morbidity and mortality particularly in subSaharan Africa. Our work traverses multiple fronts including:
- basic genomics understanding the nature and pattern of genetic variation in the parasite
- how host variation impacts disease and the parasite
- examining the immune response and parasite antigenic diversity towards improving vaccines
- the evolution of antimalarial drug resistance to predict and control its development and spread
- integrating genetic analyses into ecologic and immunologic models and frameworks
Burkitt lymphoma and Epstein Barr VirusIn malaria endemic regions Burkitt lymphoma is a major childhood cancer due to interactions of both Plasmodium falciparum malaria and Epstein Barr Virus. Our laboratory is interested in understanding tumor etiology and oncogenesisis. We are most interested in the role of variation in the infectious agents that may impact Burkitt lymphoma as well as tumor evolution and driver mutations. For this work we deploy a wide array of genomic tools in collaboration with virology and immunology collaborators.
Type 1 DiabetesWe are working with collaborators to dissect the role of variation within the T cell receptors. Autoimmunity is a consequence of the infectious milieu over evolutionary time that leaves humans susceptibility. T cell receptor variation has not been closely studied despite its role as main interface with HLA proteins.
Babesia microti, a intracellular red cell parasite and distant relative of plasmodium, is a major emerging pathogen in the Northeast and Midwest transmitted by Ixodes ticks. We have several project investigating genetic variation (extremely low) and optimizing methods of detection.
Molecular blood typing
Antigenic variation on red cells is significant cause of blood incompatibility and hemolytic reactions as allogenic transfusions are recognized as nonself. These differences have been driven in the past often by infectious agents such as malaria. With Drs Lane and Westoff to develop high-throughput tools for clinical and epidemiological applications using targeted next generation sequencing.