Choroquine resistance in Plasmodium vivax


One of the last chimpanzee studies at the NIH allowing for sporozoites from a genetic cross between Plasmmodium vivax resistant and wild type parasites to progress through the liver stage and form blood stage parasites.  Julia Sa and the Wellems group and an extensive list of collaborators (including the Bailey and Juliano labs) published an extensive "systems genetics" analysis of the   cross. The Juliano and Bailey lab performed the genome sequencing and analysis.

You can read it in full here. 

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
Juliana M. Sá, Sarah R. Kaslow, […] Thomas E. Wellems 
Nature Communications volume 10, Article number: 4300 (2019)